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Product Specifications Storage & Handling Conditions Temperature: Store at 20C to 25C (68F to 77F) Light Protection: Store in original amber vials to protect from light Humidity: Keep in dry conditions, avoid moisture exposure Shelf Life: 24 months from manufacture date when stored properly After Opening: Use within 4 hours of first puncture Important Safety Information Professional medical supervision required for administration

10.3389/fphar.2014.00196 43

cruzi (metacyclics and trypomastigotes) can actively invade a variety of non-immune and immune cells and also may be phagocytosed by macrophages and dendritic cells (reviewed in Walker et al., 2013)

Medically Reviewed By: Karla K

Moreover, curcumin interferes with signaling cascades such as mitogen-activated protein kinases (MAPKs) and AP-1, and it can activate peroxisome proliferator-activated receptor-gamma (PPAR-), all of which further skew cells toward an anti-inflammatory phenotype (Davoodvandi et al., 2021)