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doi: 10.47957/ijpda.v12i1.568 133

Ann Arbor: The University of Michigan Press

It sounds profoundbut it misses the point

These processes play key roles to promote chemoresistance in tumors, where elevated GSH inactivates electrophilic chemotherapeutic agents (cisplatin, alkylators), GSTs enable drug conjugation, and MRP-catalyzed efflux reduces intracellular drug levels - while inhibiting therapy-induced oxidative stress at the same time