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Lifelong endurance training (more than 3 times/week) lower DNA methylation in 714 gene promoters, including those associated with glycolysis, glycogen metabolism, muscular dystrophies, and oxidative stress response in skeletal muscle of the elderly, potentially enhancing the expression of genes involved in muscle metabolism and myogenesis, while the methylation levels of introns, CpG islands and exons appear similar between physically active and inactive groups [132]

Furthermore, mast cells regulate T cell responses in arthritis animal models by promoting the proliferation of CD4 + T cells and Th1/Th17 cytokines (136)

Because each organ faces different oxidative pressures, a dose that supports one tissue could, in theory, overshoot another