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Yuan et al., 2016), but also enhance the sensitivity of cancer cells to chemotherapy drugs or metabolic signaling inhibitors (Xie et al., 2016

Therefore, a comprehensive understanding of the complex mechanisms of these two types of metabolic cell death is highly important for the development of therapeutic targets in the field of oncology

The mevalonate pathway is involved in the synthesis of selenoproteins, including the active center of GPX4

Rom J Diabetes Nutr Metab Dis 20(2):149155 Shenouda SM, Widlansky ME, Chen K, Xu G, Holbrook M, Tabit CE et al (2011) Altered mitochondrial dynamics contributes to endothelial dysfunction in diabetes mellitus

Ophiopogon japonicus and its active compounds: a review of potential anticancer effects and underlying mechanisms