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The Antiaging Activity of Ergothioneine in UVA-Irradiated Human Dermal Fibroblasts via the Inhibition of the AP-1 Pathway and the Activation of Nrf2-Mediated Antioxidant Genes

doi: 10.1093/nutrit/nuv110 [DOI] [PMC free article] [PubMed] [Google Scholar] 169.Kim SSR, He X, Braverman LE, Narla R, Gupta PK, Leung AM

For example, spermidine/spermine N1-acetyltransferase 1 ( SAT1 ), a tumor protein p53 (TP53) target gene, mediates the expression of ALOX15 (but not ALOX5 and ALOX12) and is involved in TP53-mediated ferroptosis in H1299 cells

Severe forms of congenital or acquired airway flaccidity are troublesome pathologies that are difficult to treat with a mortality as high as 80%.[103] Supportive care with a tracheostomy or positive airway pressure may be insufficient and there may not be good surgical options, including anterior or posterior pexying of the airway.[104][105][106] Internal airway stenting carries a significant risk of device migration and airway obstruction or formation of granulation tissue.[107][108] Resorbable internal stents require careful surveillance due to short resorption time and possible device migration.[109][110][111] External splints using polytetrafluorethylene (PTFE) prostheses have significant risks of death, restenosis, and airway perforation.[99][100] 3D-printed tracheal splints using resorbable polycaprolactone (PCL) have had good success in patients with severe tracheobronchomalacia at high risk of death or permanent disability

Barde YA, Edgar D, Thoenen H