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Evidence level: Moderate - peer-reviewed studies in humans

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How its given and how often is very important for treatment

Induction of cyclo-oxygenase-2 in human endothelial cells by SIN-1 in the absence of prostaglandin production

10.1007/BF02505036 Arch

Amongst these genes in common to more than one timepoint, the upregulated genes included methionine sulfoxide reductase A ( MsrA , also known as Eip71CD ), transporters ( CG3036 and CG8785 ), genes related to lipid metabolic processes ( Lipid storage droplet-2 ( Lsd-2 ) and Acetyl Coenzyme A synthase ( AcCoAs )), and serine proteases ( CG18180 and Jonah 99Fii ( Jon99Fii )) (Fig