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PERK controls bone homeostasis through the regulation of osteoclast differentiation and function

Acknowledgements This review was supported by the National Natural Science Foundation of China (82373039) and the University-Industry Collaboration Program (New Drug Targets and New Molecule Discovery and Technology 8210040001, 2020-019)

The average weight loss after 72 weeks of treatment was 1520% (compared to 3.1% with a placebo), and 3057% of participants lost at least 20% of their body weight [118]

Physiological changes characteristic of the disease include mucus hypersecretion, ciliary dysfunction, airflow limitation, pulmonary hyperinflation, gas exchange abnormalities, pulmonary hypertension, and cor pulmonale, and they usually develop in this order over the course of the disease

parapsilosis breakthrough infections during echinocandin prophylaxis, suggesting more nuanced resistance dynamics (Zhai et al., 2024)