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By inhibiting drug efflux pumps, suppressing pro-survival pathways (e.g., NF-B, PI3K/Akt/mTOR), and augmenting apoptotic signaling, curcumin can lower the effective dose of chemotherapy required to achieve a desired cytotoxic effect, potentially reducing dose-limiting toxicities

REcN-F/Ca exhibits enhanced reactive oxygen species tolerance through upregulated antioxidant enzymes and hydrogen sulfide-mediated redox balancing, alongside improved gastrointestinal survivability

Figure 1 Cell Viability Cell viability was determined using the CCK-8 assay kit (Beyotime Biotechnology, Shanghai, China)

Prefiltered expression matrices with UMI counts were downloaded from the GEO Database with accession number GSE149698

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