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It should be noted that for benchmarking purposes we recommend using LogS expressed in mole fraction, as it provides a dimensionless and cross-solvent comparable target, while mass-based solubility (LogS(g/100 g)) is more usable for practical relevance 39 , also being a proper target for ML models development

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These can include nausea, vomiting, diarrhea, constipation, abdominal discomfort, reflux, and reduced appetite