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Cytokine mechanisms of central sensitization: distinct and overlapping role of interleukin-1beta, interleukin-6, and tumor necrosis factor-alpha in regulating synaptic and neuronal activity in the superficial spinal cord

The models in each case are presented in Figure 3

miR-21 also contributes to Th17 differentiation by inhibiting the caspase pathway [52], promoting RORt expression, and enhancing TGF-/Smad signaling [53, 54]

Upon oxidation, bilirubin is converted into various forms of bilirubin oxidation metabolites (BOMs), comprising at least seven hydrophilic metabolites that are promptly excreted into urine because of their hydrophilic nature (132)