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Similar content being viewed by others Introduction Colistin is a polymyxin antibiotic that has been available for clinical use since the 1960s, but was replaced shortly thereafter with supposedly more tolerable antibiotics

In recent years, extensive research (Figure 2) has shown that TMAO can activate the inflammasome NOD-like receptor protein 3 (Nlrp3) through different pathways to activate the inflammatory signal pathway, resulting in aggravation of oxidative stress and, in turn, of endothelial dysfunction