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We point out the potential parallels between ALD/AMN and inflammatory relapsingremitting/primary progressive MS, also at times manifesting as highly aggressive tumefactive disease (Marburg variant)

[4] The coordination chemistry is what makes this possible

In summary, age-dependent changes such as increased catalytic iron levels, weakened antioxidant defenses, elevated mitochondrial-derived oxidative stress and sustained membrane vulnerability to peroxidation, collectively place neurons in the aging brain in a fragile state

Neuropharmacology, 171, 108104

Additional insight is obtained from the analysis of energy density components at the BCP (Fig