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This origin explains why the peptide shows such powerful tissue-protective and regenerative properties throughout the body

GPR146 deficiency protects against diet-induced obesity in mice MASLD is often accompanied with obesity and insulin resistance 1

TJs localised at the apex of the lateral membrane of IECs are often referred to as apical junction complexes and are composed of the apical-most TJs, adhesion junctions and desmosomes, each of which are involved in the separation of apical and basolateral membrane domains and maintaining gut barrier integrity (Turner and Turner 2010

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