acetaminophen toxicity glutathione depletion Clinically relevant therapeutic approaches against hepatotoxicity and acute liver failure Too much paracetamol = dangerous

Too much paracetamol = dangerous because of how your liver processes it. *Normal dose:* About 90 95% gets broken down safely by glucuronidation + sulfation non toxic stuff you pee out. *The problem The Metabolism of Acetaminophen and the Synthesis of Glutathione Download Scientific Diagram Acetaminophen induces liver injury and depletes glutathione in mice brain: Prevention by Moringa oleifera extract ScienceDirect A 48 hour fast can turn standard Paracetamol into acute liver failure. Fasting depletes Glutathione, leaving the liver defenseless against toxic NAPQI. Review the latest guidelines on BMJ Best Practice: https: bestpractice.bmj.com topics en us 1010 Comment FEVER for links to alternatives in post Lets go through some basics: Paracetamol reduces fever and pain by acting in the brain. The body breaks it down mostly in the liver

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