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Anti-stress and Anti-ROS effects of MnOx-Functionalized thermosensitive nanohydrogel protect BMSCs for intervertebral disc degeneration repair

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doi: 10.1111/fml.2009.294.issue-1 70 Den BestenGVan EunenKGroenAKVenemaKReijngoudD-JBakkerBM

In vitro experiments demonstrated that Akt inhibition markedly upregulated the expression of FTL, FTH, TFR1, and Poly (rC)-binding protein 1 (PCBP1), downregulated FPN1 expression, increased APP expression, enhanced iron storage and uptake, and decreased iron efflux, thereby aggravating neurological injury in SH-SY5Y and C2C12 cells (Halon-Golabek et al., 2024)

These shots are typically given right into a muscle, like your upper arm or thigh