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Antisense oligonucleotide mediated increase of OPA1 expression using TANGO technology for the treatment of autosomal dominant optic atrophy

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Pediatr Nephrol 2010;25:557-560

4.2.4 PPAR signaling pathway The PPAR signaling pathway is a central regulator of cellular metabolism, playing a crucial role in lipid metabolism, energy homeostasis, and autophagy regulation ( PPAR plays a central role in regulating metabolism and autophagy, making it a crucial target for drug development in disease treatment

Together these results suggest that ORF3a induces mROS production to activate HIF-1, which in turn triggers a shift in cellular metabolism to favor glycolysis, resulting in increased viral replication and transcription of pro-inflammatory cytokines