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cOR = 1.58

Samples were prepared in triplicate and were stored in the dark at 42 C with 25% relative humidity (RH) in an accelerated degradation chamber, as 2 weeks storage under these conditions is equivalent to approximately 6 weeks storage under ambient conditions [29, 30]

Furthermore, the expansion of pathobionts like Peptostreptococcus can generate detrimental metabolites (e.g., indole derivatives), which directly upregulate cartilage-degrading MMP-13 (2628)

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Given the crucial roles of folate and vitamin B12 in DNA synthesis, deficiencies of these vitamins can lead to impaired DNA synthesis, which may contribute to disruptions in cell proliferation, differentiation, and function