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Using in vitro assays, the study demonstrated that methanol and aqueous extracts of Phlomis tuberosa significantly inhibited CA II activity, with IC 50 values of 16.31 g/mL and 20.37 g/mL, respectively

Then, using a spectrophotometric device (SpectraMax M2

Phase 2 metabolism involves conjugation of water soluble moieties attached to the drug, which plays a role in detoxification and facilitates excretion

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Henkenberens C, Janssen S, Lavae-Mokhtari M, Leni K, Meyer A, Christiansen H, et al