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There are two apoptotic pathways: the extrinsic pathway, which is activated by death receptors, and the intrinsic pathway, which can be activated by hypoxia and oxidative stress that occur due to cardiopulmonary bypass [8, 9]

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In patients with cystic fibrosis (CF), who experience elevated elastase levels in the airways, increased iron and ferritin concentration have been observed in sputum and bronchoalveolar lavage samples ( In individuals with A1AT deficiency, with Z and S polymorphisms, there is a significant accumulation of iron in the liver ( Studies have also reported significant differences in plasma ferritin concentrations between individuals with different A1AT genotypes