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Its a naturally occurring compound whose secretion occurs in the bloodstream

The following are some of the stressors that may lead to adrenal fatigue: Anger Depression Chronic illness Over-exercising Chronic infections Fear and guilt Chronic pain Gluten intolerance Hypoglycemia Malabsorption Digestive problems Exposure to toxic chemicals Surgeries Sleep deprivation Excess sugar in the diet Excess caffeine among others How do stressors affect the body

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AMPK and other signalling pathways, such as the insulin/IGF-1 signalling (IIS), rapamycin-targeting protein (mTOR), nuclear factor-B (NF-B), and deacetylase (Sirtuins) pathways, interact with each other to form a complex network closely related to longevity and ageing [76, 100]