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The downstream signaling cascade of PI3K is associated with several effector proteins, including AKT, serum, and glucocorticoid-induced kinase (SGK), both of which can upregulate cellular ENaC by inhibiting the ubiquitination of Nedd4-2 (Hou et al., 2022

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However, given the lower intracellular GSH:GSSG ratio after IL-13 stimulation, it is difficult to determine the proportionate role that loss of GSH plays in downstream T2-pathway mRNA/protein expression