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Activation of SIRT1 can enhance the antioxidant capacity of cells by deacetylating key proteins such as Nrf2 and p53, reduce the production of ROS, and inhibit lipid peroxidation, protecting nerve cells from the damage caused by ferroptosis by regulating proteins related to iron metabolism and antioxidant defense mechanisms such as Nrf2, GPX4, and FTH1

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[DOI] [PMC free article] [PubMed] [Google Scholar] 126.Yagishita Y., Fahey J.W., Dinkova-Kostova A.T., Kensler T.W

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