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The -helical domain packs against the catalytic domain and the catalytic triad (His86, Asp224 and Ser657) of the catalytic domain lies at the interface between the two domains (Fig

Another promising marker is soluble CD163 (sCD163), a macrophage activation marker that reflects hepatic macrophage activity

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These mechanisms affect synaptic plasticity, energy metabolism, and the integrity of the gutbrain barrier