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458 Maintaining a stem-like phenotype necessitates the activation of diverse signaling cascades, including the Wnt, Notch, and Hedgehog pathways

10.1016/j.optmat.2020.110450 221 SunH.ZhouY.RenJ.QuX

J Hepatol 2017;67:508-516

However, cancer cells can activate compensatory pathways to overcome glutaminolysis inhibition

Moreover, the simultaneous inactivation of Nrf2 and blocking of TGF- signaling can completely reverse the inhibitory effect of AF on p38 MAPK phosphorylation