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Funding Statement This work was supported by Japan Science and Technology Agency (JST) CREST Grant Number JPMJCR2024 (20348438 to T.A.), Grant-in-Aid for Scientific Research on Innovative Areas(A) Sulfur biology (21H05263 and 21H05258 to T.A.), International Leading Research (23K20040 to T.A.), Scientific Research (S) (24H00063 to T.A.), from the Ministry of Education, Culture, Sports, Science and Technology of Japan, and Japan Agency for Medical Research and Development (AMED) to T.A

HNE disrupts this balance by inhibiting Keap1, leading to upregulation of Nrf2 (Levonen 2004

Nucleotide precursor analogs are developed as anti-cancerous therapies to exploit cancer cells preference for the salvage pathway in purine and pyrimidine synthesis

Long-term safety data in humans does not exist for most injectable peptides

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