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Therapeutic Research Protocol Dose: 0.5 0.9 mg (= 1018 clicks) Duration: 3 4 weeks Frequency: 2 daily, divided doses Cycle Interval: 4 weeks off before repeating Goal / Description: Higher-dose protocol used in stress-response and GABAergic modulation studies

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Research has found associations between these genes and analgesic needs in both acute and chronic pain conditions, as well as pain sensitivity (Table 1).25,155159 The Genetic Addiction Risk Score (GARS) can help predict patient responses to opioids, facilitating personalized opioid analgesic therapy (Figure 7).155 Candidate genes, such as catechol-O-methyl-transferase and MORs, have been linked to analgesic requirements and pain sensitivity.158160 The GARS test measures risk polymorphisms across 10 reward genes (Figure 8)