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Taken together, these findings demonstrate that the 10 mg/kg morphine model recapitulates the known effects of opioids in humans, inducing constipation through inhibition of both intestinal transit and motility

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Makin AJ, Williams R

2015;104(2):312-317.e1

Vanadium acts as a powerful insulin mimetic by inhibiting Protein Tyrosine Phosphatase-1B (PTP-1B), an enzyme that normally deactivates the insulin receptor