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doi: 10.1021/acs.jafc.9b04741 100 DouT.ZhangK.ShiX.LiuW.YuF.LiuD

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The Poptosis Mechanism PNC-27 kills cancer cells through a four-step membrane-directed mechanism distinct from conventional apoptosis pathways: Step 1 Target Recognition: PNC-27s p53-derived domain (residues 1226) adopts an HDM-2-binding conformation confirmed by NMR structural studies to be directly superimposable on the structure of the same p53 residues when bound to HDM-2

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