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More recently, a family of potent and highly selective mechanism-based suicide substrate inhibitors were developed and shown to promote the irreversible inhibition of gut microbiotadependent generation of TMA, suppression of host TMAO levels, and, in parallel, inhibition of platelet hyperresponsiveness and thrombosis potential in animal models (22)

[DOI] [PubMed] 31.Berezhnov AV, Fedotova EI, Nenov MN, Kasymov VA, Pimenov OY, Dynnik VV

Transfection of fluorescent LC3 constructs The plasmids of pEX-GFP-hLC3WT and Ds-RFP-GFP-LC3 (pQCXI Puro DsRed-LC3-GFP) used in the present study were provided by Drs

10.1016/j.trsl.2018.10.002 23 BerdyskiM.MisztaP.SafranowK.AndersenP

Amino acid metabolism in immune cells: essential regulators of the effector functions, and promising opportunities to enhance cancer immunotherapy