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Such probabilities are often described in a matrix and are used by some algorithms (e.g., BLAST, CLUSTALW, GAP, etc.) in calculating percent similarity wherein similarity refers to the degree by which one amino acid may substitute for another amino acid without lose of function

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10.1111/j.1365-2125.2004.02194.x 37 WangH.XiS.LiuZ.YangY.ZhengQ.WangF.et al (2013)

All quantitative efficacy data (body-weight loss, fat-mass reduction) comes from a single diet-induced-obese mouse study

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