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Although the moonlighting functions of these metabolites, including their roles in signaling, post-translational modification, and epigenetics are being increasingly appreciated (10), how they regulate the extent of inflammation by coregulating inflammatory and anti-inflammatory pathways remain unclear

Standardized mean differences (SMD) and 95% confidence intervals were calculated for each outcome using a random effects model [24]

Surprisingly, mice with specific genetic deletion of Gpx1 appear phenotypically normal and with normal life span (Ho et al., 1997), suggesting that there are alternative compensatory mechanisms for H 2 O 2 scavenging in Gpx1 deficiency