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doi: 10.1093/brain/awac165 280 TristB

Free Radic Biol Med 20(7):933956

41 NalczK

Tregs have increased transcript levels of the amino acid sensors Sestrin1, CASTOR1, CASTOR2 as well as components of the GATOR1 and GATOR2 complexes

Mechanistically, IL-23 signaling through its heterodimeric receptor (IL-23R/IL-12R1) activates STAT3 phosphorylation (pSTAT3), which drive their commitment to a Th17-like pathogenic subseta process critical for the production of IL-17A and IL-22 (126), which in turn enhance epithelial permeability and inflammatory infiltration in the gut (127)