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While the etiology of most ALS patients is unknown, about 10% of patients are linked to genetic factors

1 Cysteine-directed covalent warheads are already a component of many FDA-approved drugs and advanced chemoproteomic studies have uncovered thousands of additional cysteines that can be covalently modified by small molecules

Additionally, a study reported a significant increase in the frequency of LDNs in the circulating blood of patients with COVID-19, which correlated with the severity of the disease, particularly in severe or critical patients

Precautions are also vital for patients with severe kidney impairment

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