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FOXO transcription factors in antioxidant defense

Maslova et al

Thangamani, L

P63+ progenitor cells are known for their ability to regenerate the tissues of the airways, and previously we and other scientists have shown in animal experiments that they can repair the damaged epithelial tissue in the alveolithe tiny air sacs in the lungs that play a crucial role in the exchange of gases between air breathed in and the blood supply to the lungs. In this first phase I clinical trial, the researchers set out to investigate the efficacy and safety of taking P63+ progenitor cells from the lungs of 20 COPD patients, using them to grow millions more in the laboratory, before transplanting them back into the patients lungs

Bakhtiarian, Toxicology Mechanisms and Methods 18, (2008) 351354