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Some users develop chronic constipation requiring fiber supplementation, increased water intake, or occasional use of osmotic laxatives like polyethylene glycol

72 It has been suggested that this lack of ghrelin suppression may lead to higher food consumption and add to the pathophysiology of obesity

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At the age of 42 years she developed an abdominal swelling and was found to have an obstructed incisional hernia for which she had surgery including bowel resection