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One critical safety note: glutathione depletes zinc and selenium over prolonged high-dose use because it relies on these minerals as cofactors for glutathione peroxidase and glutathione reductase enzymes

Exploring TNFR1: from discovery to targeted therapy development

Moreover, in models of ischemiareperfusion injury and in KEAP1-inactivated lung cancer, inhibition or genetic ablation of CoQ biosynthetic enzymes restored sensitivity to ferroptosis or radiotherapy 115,116 , underscoring the reliance of some cancer cells on an abundant CoQ pool for redox defense and survival

Benefits have also been shown in low back pain, autistic spectrum disorders and aphthous ulcers, although this is based on small numbers of clinical trials

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