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The inclusion criteria applied at this step were: use of acetylcysteine for acute acetaminophen overdose, use of acetylcysteine subsequent to a 4 to 24 hour acetaminophen level above the Rumack-Mathews treatment line (either the 150 line or the 200 line), no evidence of hepatotoxicity prior to acetylcysteine treatment, and a reported AST or ALT activity post acetylcysteine treatment

The precise control of GC production and secretion is vital for restoring homeostasis after stress exposure, primarily through feedback regulation of the hypothalamo-pituitary-adrenal axis (HPA)