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These effects are mediated through inhibition of the NF-B/NLRP3/caspase-1 and Bax/Bcl-2/caspase-3 pathways, alongside activation of Nrf2/HO-1, p-AMPK, and -Klotho signaling (Khallaf et al

doi:10.3389/fgene.2023.1159167 125

Cell Mol Biol Res

By fusing these promoter sequences to lacZ gene, we successfully certified that 8 out of 22 candidates exhibiting high -galactosidase activities that are 35 times higher than the control promoter P hsp60 (Figure 10)