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Moreover, considering the relevance of the discussed adhesion molecules and metabolic players, additional therapeutic interventions must be considered

Fingolimod, a well-established sphingosine-1-phosphate receptor agonist, alleviates neurological deficits and reduces infarct areas by enhancing Akt signaling and ameliorating neuronal apoptosis, 401,402 as well as regulating the mTOR/p70S6K autophagy signaling pathway in ischemic stroke models

doi: 10.1074/jbc.M510916200 134 FreedmanJCNovakTS

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demonstrated that the molecular clock is involved in the regulation of anerobic glycolysis via HIF1 signaling and that circadian control of HIF1 affects glucose metabolism in a context-dependent manner 44