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Melatonin as a potent and widespread anti-inflammatory agent Several studies have shown that melatonin can regulate the activation of the immune system, reducing chronic and acute inflammation 70,71,72,73

The repetitive triggering of C-fibers during migraine attacks and the resultant stimulation of CGRP-mediated pain pathways keep the TVS in a state of heightened sensitivity, thus contributing to the progression of migraine into a chronic condition (10, 33)

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However, the induction of starvation-induced bulk autophagy, which does not activate TBK1, did not lead to a phosphorylation of GABARAPL2 (Figs

Weiwer M, Bittker JA, Lewis TA, Shimada K, Yang WS, MacPherson L, et al