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Per unit of glucose, glycolysis is an inefficient means of generating ATP compared to the amount obtained by mitochondrial respiration

When most of the glucose in glycogen stores is used up, digestion of fatty acids in the liver is upregulated, but under these circumstances, energy metabolism hardly can proceed beyond the generation of acetyl-CoA

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Studies have indicated that GLUT9 serves a crucial role in the transport of UA from intracellular to extracellular spaces and participates in urate reabsorption at the apical membrane of renal proximal tubules (38,39)