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Differences in results are due to a combination of factors including ascorbic acid-related concerns (doses, administration routes, plasmatic levels, metabolites recording, and source), cancer characteristics (specific mutations present, type and grade of cancer, received conventional anti-cancer therapy), and individual characteristics (diet, behaviors, genetics, transporters)

This dysregulation is partially mediated by alterations in the NKCC1/KCC2 expression ratio, which governs intracellular chloride gradients and GABAergic polarity (see Section 'Disruption of Neurotransmitter Balance by Anesthetics'), as well as through direct interference with the functional integrity of GABA A Rs and NMDA receptors (Cabrera et al

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Calcifediol Treatment and Hospital Mortality Due to COVID-19: A Cohort Study