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Recently, DNA sequencing-based techniques have enabled genome-wide, high-resolution mapping of DNA damage, including DNA strand breaks and oxidative base modification 190,191

10.3389/fpls.2013.00372 Front

However, total alpha-synuclein in the CSF, does not show a consistent relationship with Lewy body pathology, or change over time in relation to motor or cognitive measures 8,9 , and quantification metrics of the alpha-synuclein SAA are not yet validated or robust across different laboratories