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10.1038/nrd.2015.6 23 CrawfordR

The enrichment gene sets with a p -value 0.05 and a false discovery rate (FDR) 0.25 in the GSEA were considered to exhibit statistically significant differences

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However, pediatric pharmacokinetics are distinct from adults due to developmental variability in hepatic enzyme expression, renal clearance, and bloodbrain barrier permeability

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