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These metabolites are typically interpreted as markers of neuronal health, bioenergetics, membrane integrity, excitation, and inflammation, respectively 10

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Details on how the square-wave functions were implemented in the model are shown in the Supplementary Methods (NONMEM code)

pmid:23153705 24

Given the potency of this disinhibition of tonically active BNST afferents, other activators of the HPA axis, such as psychological stress, may also work by reducing BNST inhibitory tone onto PVH Crh neurons