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The therapeutic era of peptides began in 1921 with the discovery of insulin, a breakthrough that revolutionized diabetes and helped establish biologic therapies in medicine Since then, peptide hormones like oxytocin and human growth hormone (GH) have entered clinical use, and glucagon-like peptide-1 (GLP-1) receptor agonists such as semaglutide are now widely prescribed for obesity and metabolic diseaseconditions increasingly recognized for their effect on orthopaedic outcomes

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The 5-aminosalicylic acid (5-ASA) treatment blunts the increase in circulating TMAO in mice on the choline-supplemented high-fat diet (Woongjae Yoo et al., 2021)

Brain inflammation is accompanied by peripheral inflammation in Cstb (/) mice, a model for progressive myoclonus epilepsy