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Women of childbearing potential should use effective contraception during treatment and discuss with their healthcare provider if planning pregnancy, as tirzepatide should be discontinued at least 2 months before a planned pregnancy

Case 252: acute hyperammonemic encephalopathy resulting from late-onset ornithine transcarbamylase deficiency

For neurological involvement, hydroxocobalamin 1mg should be given on alternate days until no further improvement, before moving to maintenance

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p53 deacetylation alleviates calcium oxalate deposition-induced renal fibrosis by inhibiting ferroptosis