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Schulte-Hermann, R., and Parzefall, W

doi: 10.1016/j.clim.2023.109778 82 DangQSunZWangYWangLLiuZHanX

It is mostly caused by the mutation of the trinucleotide CGG expansion in the 5-untranslated region of the fragile X mental retardation ( FMR1 ) gene, which eventually leads to the absence of its protein product, fragile X mental retardation protein (FMRP) (Garber et al., 2008