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The depletion of cytosolic glutathione by import into the nucleus induces glutathione synthesis, which accelerates the accumulation of GSH and allows the maintenance of a reducing redox environment under stress conditions (Diaz Vivancos et al

Unlike harmless commensal bacteria, microbial pathogens release an array of toxins or virulence factors that can alter cellular physiology and cause the release of DAMPs 1 , whose detection is instrumental in activating innate microbe-killing mechanisms

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Swelling in extremities or facial puffiness is common