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The logic is to pair cognitive activation (Semax) with calmer stress handling (Selank)

This NAD+ elevation activates sirtuins, particularly SIRT1 in adipocytes and hepatocytes, which deacetylates and activates numerous metabolic regulatory proteins including PGC-1, a master regulator of mitochondrial biogenesis, oxidative metabolism, and thermogenesis

It slows digestion and decreases appetite, which can help individuals eat less and lose weight

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A similar subtle gray matter pathology has also been described in the MS brain